On March 16, 2025, Ke'ai Shi, a rising domestic brand in the anti-wrinkle field, and Guangzhou Yangsen Pharmaceutical officially signed a comprehensive strategic cooperation agreement at the Guangzhou Baiyun Yangsen Industrial Park. Both parties will focus on the mature skin segment of the silver hair economy, based on a deep collaborative model of "R&D and production + market operation," to create an innovative benchmark in the anti-wrinkle field using "gene technology + biomimetic membrane technology." This cooperation marks a key step for Ke'ai Shi in transitioning from a regional brand to a national and even global market, and also provides a new solution for beauty industry physical stores to break through the difficulties of declining consumption.

Focusing on the forefront of technology

——R&D and market dual-drive, building a closed-loop anti-wrinkle ecosystem

According to the agreement, Yangsen Pharmaceutical will be fully responsible for the R&D, production, and brand endorsement of Ke'ai Shi products. Relying on its exclusive patented ingredient "Yangsen Core" and biomimetic membrane technology, it will simulate the human skin barrier structure to improve the moisturizing and anti-wrinkle efficacy of the products. Ke'ai Shi will focus on market recruitment, training, operation, and sales, and will invest 20% of its annual sales performance into the Yangsen R&D Innovation Center to jointly develop new gene-regulating products for mature skin. Both parties have also established a dynamic feedback mechanism, with Ke'ai Shi using market data to reversely promote R&D optimization, forming a "demand-R&D-application" closed loop.

Technology Highlights

1. Gene Technology: Based on the mechanism of skin aging genes, develop ingredients that can regulate the expression of type 17 collagen to precisely improve the aging condition;
2. Biomimetic Membrane Technology: Construct a skin-like barrier protective film in skincare products to enhance moisturizing and anti-irritation capabilities;
3. Integration of Cutting-Edge Black Technologies: Combining plant exosomes, stem cells, peptides, microcapsule liposome encapsulation transdermal absorption, and other technologies to improve the targeting and long-lasting effects of anti-wrinkle ingredients.

Market Strategy

——Empowering physical beauty industry, national recruitment layout global

Ke'ai Shi founder Wang Xin (20 years of experience in the beauty industry, former training/marketing director of an internationally renowned chain brand) stated that Ke'ai Shi will be fully upgraded to a national recruitment platform in 2025 and will launch a global layout, providing a "top ten empowerment system" for cooperating businesses, including self-sales systems, card item design, team training, etc., to help small and medium-sized

beauty salons increase their performance by more than 30%.

Core Strategies

Precise Customer Group Positioning: Focusing on workplace groups (such as PPT workers, business people), targeting problems such as skin sagging and insufficient blood oxygen caused by prolonged sitting, launching projects such as "Bamboo Face Carving" and "Layered Oxygen Anti-wrinkle," focusing on the emotional value of "shaking off workplace anxiety" and "reshaping 35 years old."

Technology + Service Dual Drive: Integrating handcrafted operations (such as fascia reconstruction, small face bone setting) with scientific ingredients to create a differentiated experience and enhance customer stickiness.

Industry Background and Regional Advantages

As a national highland for beauty, biology, and health industries, Guangzhou has accelerated the industrialization of innovative achievements in recent years through policy support (such as the "Beauty and Biology 2.0" full-chain support system), industry-academia-research cooperation (such as the Guangna Institute's nanotechnology transformation platform), and international resource links. Yangsen Pharmaceutical is rooted in the Guangzhou beauty and biological cluster, and this cooperation is expected to leverage regional advantages to further consolidate its leading position in R&D in the anti-wrinkle field.

Founder's Vision

——Practical empowerment, climbing the peak of the beauty industry together. Ke'ai Shi founder Wang Xin emphasized: "It's not easy for physical stores to survive, but we provide practical solutions for cooperating businesses with a 'system + tools + practical model.' Through five years of development, the brand has expanded from an 80-square-meter apartment store to 14 directly-operated chain stores and more than 500 cooperative stores. Its "executive training - team building - customer fission" system has a good reputation in the industry. In the future, Ke'ai Shi plans to cooperate with Yangsen Pharmaceutical to promote anti-wrinkle products into more international markets and create a benchmark for Chinese gene anti-wrinkle brands.

Conclusion

This cooperation is not only a resource integration between enterprises but also a microcosm of the full-chain collaboration of "R&D-transformation-market" in Guangzhou's beauty and biological industry. With the rise of the silver hair economy, the innovative model of Ke'ai Shi and Yangsen Pharmaceutical may provide the industry with a new paradigm of "technology empowering entities."