—— A scientific leap from damage repair to firming and anti-wrinkle skincare

In the field of firming and anti-wrinkle skincare, “collagen” has always been the core keyword. But did you know that there are actually 28 types of collagen in the human body? Among them, type III collagen, due to its strong association with infant skin, is known as "youth collagen." In recent years, with breakthroughs in biotechnology, this ingredient, once only used in medical wound repair, is sweeping the skincare market as "anti-wrinkle black technology," redefining youthful skin.

Scientific Tracing: III type collagen's " Life Code ”

Collagen is the most abundant protein in the human body (approximately 30%), forming the "steel frame" of the skin. Among them:

I type collagen: accounts for 80%-90% , thick and strong, maintaining skin firmness;

III type collagen: accounts for 10%-15% , thin and soft, dominating skin elasticity and repair ability.

III The special nature of type III collagen lies in:

1. " Infant skin ” Guardian: : In fetal skin, III type III collagen accounts for a high percentage, 60% , but with age, its synthesis ability decreases sharply, 30 years later, the content is less than 1/4 ；

2. of infancy. " Pioneer in wound repair: ” : When the skin is damaged, III type III collagen is preferentially secreted, quickly building a temporary repair network, promoting wound healing and reducing scars;

3. Aging " Barometer: ” : Its loss directly leads to thinning skin, decreased elasticity, and the appearance of fine lines.

Skincare Revolution: III Four Core Combat Strengths of Type III Collagen

Traditional skincare products mainly focus on supplementing type I collagen, but the molecular characteristics of type III collagen make it more groundbreaking in the field of anti-wrinkles:

1. Barrier Repair: Rebuild " Skin Ecosystem ”

By promoting the proliferation of fibroblasts, accelerating skin self-renewal;

Forming a dense network structure, strengthening the stratum corneum's water-locking ability (tested, using products containing III type III collagen 28 days later, transepidermal water loss decreased 37% ).

2. Dynamic Anti-wrinkle: Activate " Youth Signals ”

Stimulate cells to secrete integrins and laminins, improving the tightness of the dermo-epidermal junction;

Inhibit metalloproteinases ( MMPs ) decomposition of collagen, delaying wrinkle formation.

3. Redness Reduction and Stability: Sensitive Skin's " Invisible Shield ”

Downregulate IL-6、 TNF-α and other inflammatory factor expressions, relieving redness and stinging;

Repair UV-induced DNA damage, reducing the risk of photoaging.

4. Microecological Balance: Precisely Regulate " Microbial Dialogue ”

Research by Janssen Pharmaceutica's R&D Innovation Center has found that III type III collagen fragments can regulate skin microbiota diversity and inhibit the overgrowth of Cutibacterium acnes.

Technological Breakthrough: From " Difficult Extraction ” To " Biomanufacturing ”

Natural Type III collagen has faced three major bottlenecks: difficulty in extraction, poor stability, and large molecular weight making it difficult to penetrate. Today, breakthroughs in biotechnology have brought new solutions:

Recombinant humanized technology : Using genetically engineered CHO cells or E. coli to mass-produce type III collagen that is 100% homologous to the human body; III 型胶原；

Micro-molecular peptide technology : Cutting collagen into 500Da small molecules, increasing transdermal absorption rate to 80% or more;

Freeze-drying preservation technology : Through -196℃ liquid nitrogen freezing to preserve activity, when used " Freshly Prepared ”。

Market Outlook: A Trillion-Dollar Track from Medical to Skincare

According to the Global Collagen Market Report, Type III collagen-related products have an annual growth rate of 42%, far exceeding traditional collagen categories. Its applications have expanded from high-end medical dressings (such as burn repair) to daily skincare:

Targeted Anti-wrinkle ：with A alcohol and Boseyin, etc., to build " Repair + Anti-wrinkle ” dual pathways;

Sensitive Skin Care ：Combined with panthenol and Centella asiatica extract to create " Emergency ” barrier repair solution;

Microneedle / Radiofrequency Companion ：As a core component for post-operative repair, it shortens the recovery period and improves efficacy.

“The rise of Type III collagen marks the transition of anti-wrinkle skincare from 'extensive supplementation' to 'precise regulation.'”—Yangsen R&D Innovation Center ： Combining synthetic biology and skin microbiome research, Yangsen Pharmaceutical has obtained a national invention patent “Recombinant Type III Collagen Hydrogel Composition” (Invention Patent No.: ZL202211275409.5). This invented technology, “baby collagen”, will become the key to rewriting the skin's age code.

(Friendly reminder: The mechanisms and data described in this article are based on scientific research by the Yangsen R&D Innovation Center. Please follow relevant laws and regulations for specific applications; In addition, this article introduces the efficacy of raw materials. In practical applications, products shall be subject to filing and efficacy reports, and the description of efficacy shall comply with cosmetic supervision regulations.)